High-Resolution Ultrasonic Colloid Stability Analyzer

The new HR-US Colloid Stability Analyzer is designed to enable the analysis of stability, shelf-life and effects of thermal treatment of emulsions, suspensions and other complex formulations in R&D, product development, and QA/QC environments of various industries, including pharmaceutical, food and beverage, cosmetics and personal care.

Technical parameters of the model

- Real-time detection of changes in the distribution of components in samples caused by the sedimentation or creaming with outstanding precision, allowing fast prediction of sample life-time
- Real-time analysis of aggregation and flocculation
- Real-time assessment of particle size evolution
- Excessive pressures capabilities, up to 10 bar
- Broad temperature range, -20°C to 120°C (standard) and -60°C to 140°C (extended)
- Precision temperature control, accurate to 0.02°C
- Analysis in flow and on-line capabilities
- Ease of measurement, no sample preparation
- Direct information on sample bulk properties
- Inverted Gravity Capability

Basic Principles

Destabilization of samples leading to the redistribution of components, phase separation and other unwanted effects can occur in a diverse range of colloidal type systems, ranging from simple suspensions (such as milk) to emulsions complex formulations employed in a broad range of industrial products. The figure below illustrates a typical scenario of sedimentation in a suspension of particles (or droplets) caused by an aggregation process. Initially particles are evenly distributed throughout the sample. The zoom section illustrates an aggregation of particles occurring with time. If particles are heavier than the continuous medium, the large particle aggregates will sediment or cream, if the particles are lighter. This will change the distribution of components in the sample and eventually lead to component separation. Also included is a depiction of an inverted gravity experiment where the sample can be rotated for advanced ultrasonic analysis.

 

Aggregation of particles causes their sedimentation. This is analyzed by real-time measurements of the change in the concentration and particle size in the ultrasonic beam.

 

Measurements of velocity and attenuation of the ultrasonic wave propagating through the sample allow real-time monitoring of particle concentration and changes in particle size in the ultrasonic beam. High-resolution measurements allow the detection of even minor changes, 0.0001%, in particle concentration.

 
Example:

Analysis of the stability of two suspensions with different polymer coatings, Formulations I and II.
Formulation I exhibits a fast aggregation process accompanied by sedimentation.

 
 
 

This technology is protected by granted patents and pending patent applications

 

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